2012 Jan;13(1):52-58. doi: 10.1016/j.cllc.2011.05.001.  C; National Surgical Adjuvant Breast and Bowel Project Investigators. The association of p53 with endocrine therapy outcomes was long-lasting throughout follow-up (Figure 1B). The varying course of positive and negative symptoms over time is shown in Figure 3. Clinical highlights from the National Cancer Data Base, 1999. Survival Rates Based on Axillary Lymph Node Status in Males with Breast Cancer, Table 59-3. Age was identified as an independent poor prognostic factor for OS vs high grade for RFS in untreated patients, in addition to the tumor size and number of positive axillary lymph nodes for both outcomes. Despite a timely resuscitation of patients with GSWH at the scene of accident, a large number of patients are dead on arrival (Zafonte et al., 2001a).  J, O’Meara  WF, Chen Univariate analysis and multivariate logistic regression analyses were conducted to identify all prognostic factors and independent prognostic factors, respectively. Overall, according to the National Cancer Institute’s Surveillance, Epidemiology, and End Results Statistics, survival rates for breast cancer decrease as age increases. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. doi:10.1001/jamanetworkopen.2020.7213. In contrast, the number of positive nodes (AHR, 1.13; 95% CI, 1.06-1.20; P < .005), high grade (AHR, 4.01; 95% CI, 1.51-10.70; P = .01), and ERBB2 positivity (AHR, 2.67; 95% CI, 1.25-5.70; P = .01) were significantly associated with higher risk of recurrence (Figure 3). A substantial decrease in the survival rate within 5 years had been observed in treated vs untreated patients with triple-negative breast cancer; in contrast, a low but steady decrease of survival has been observed in patients with HR-positive and ERBB2-negative breast cancer.27 Noticeably, the tumor size no longer had an independent role after endocrine therapy compared with nontreatment, consistent with the previous report in women who were treated with endocrine therapy alone in National Surgical Adjuvant Breast and Bowel Program trials.28, Herein, we also provided evidence that overexpression of p53 was significantly associated with poor survival after endocrine therapy. This observation of independence from known prognostic factors shows that these factors do not adequately explain the poor prognostic … Education Program}, year={2009}, pages={ 385-95 } } D. Grimwade, R. Hills; Published 2009; Medicine; Hematology. NDRG1 is widely described as a metastasis suppressor in breast cancer.  SX, Polley The event numbers for OS and RFS were 75 and 60, respectively, for the endocrine therapy group; 127 and 93, respectively, for the no-treatment group; 34 and 31, respectively, for the radiotherapy group; and 68 and 57, respectively, for the chemotherapy group. Histology, according to WHO classification, does not seem to be a validated prognostic factor, with the exception of thymic carcinoma. Gender and myasthenia gravis are consistently reported as not being significant predictors for either survival or recurrence. . Predictor variables in statistical analyses also are called independent variables, prognostic factors, regressors, and covariates. The data may be critical to an approach of precision endocrine therapy in the care of patients with breast cancer.31 Our results, other real-world data, and clinical trials are gathering sufficient evidence for the cancer research community and regulatory agencies to consider exclusion of p53-positive and HR-positive breast cancer from endocrine therapy or to use alternative treatment approaches.8,29,32-35 In current practice after TAILORx (Trial Assigning Individualized Options for Treatment) trial results, approximately 70% of patients with HR-positive and ERBB2-negative early-stage breast cancer receive endocrine therapy alone, which accounts for as much as 50% of all early-stage breast cancers.36, Clinical measurements (nodal status, high grade, and ERBB2) that weighted independently for RFS were different from the survival factors in the case of endocrine therapy.  C, Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 4): discriminants for 15-year survival. Meaning  ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780123742711000423, URL: https://www.sciencedirect.com/science/article/pii/B9780124409057503297, URL: https://www.sciencedirect.com/science/article/pii/B9780323523578000561, URL: https://www.sciencedirect.com/science/article/pii/B0122275551000307, URL: https://www.sciencedirect.com/science/article/pii/B978044452892600012X, URL: https://www.sciencedirect.com/science/article/pii/B9780702033964000251, URL: https://www.sciencedirect.com/science/article/pii/B9780323359559000180, URL: https://www.sciencedirect.com/science/article/pii/B9780323240987000605, URL: https://www.sciencedirect.com/science/article/pii/B9780443069017500353, IASLC Thoracic Oncology (Second Edition), 2018, The Differences between Male and Female Breast Cancer, Principles of Gender-Specific Medicine (Second Edition). INSERM, Centre d'Investigations Cliniques‐Plurithématique 1433, Nancy, France. Clin. Comparatively, it did not reach statistical significance in other monotherapy groups and the nontreatment group. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves. Limitations include a lack of randomization; however, current practice does not allow a group without treatment (except node-negative breast tumor that is 0.5 cm or smaller) and/or homogeneous therapy in patients with certain patient and tumor characteristics. Waks  HB, Polley Loss of function and p53 protein stabilization. Because this was a randomized trial, patients were either biologically selected or randomly assigned to receive a BM transplant. Multivariable Cox analysis demonstrated a significant association after radiotherapy with inferior OS for larger tumors (AHR, 2.76, 95% CI, 1.79-4.31; P < .005) and ERBB2 (AHR, 5.35; 95% CI, 1.31-21.98; P = .02) and with RFS for larger tumors (AHR, 2.27; 95% CI, 1.23-4.18; P = .01) and ERBB2 (AHR, 6.05; 95% CI, 1.48-24.78; P = .01) (Figure 2 and Figure 3). Prognostic factors for all clear cell carcinomas of the vagina include stage at diagnosis, tumor size, and grade of the lesion, including architecture and nuclear grade, and appear to pertain equally to patients both DES-exposed and DES-unexposed. Cletus A. Arciero, Toncred M. Styblo, in The Breast (Fifth Edition), 2018. Based on a general rule of statistics of using 15 events (such as death or recurrence) per variable for time-to-event end point, each treatment group had adequate statistical power for the identification of at least 2 independent prognostic variables for OS or RFS.22 The secondary objective was to compare OS and RFS between p53-positive and p53-negative patients undergoing uniform therapy as well as those without treatment by Kaplan-Meier analysis. Open Access: This is an open access article distributed under the terms of the CC-BY License. Schwab M … JAMA Network Open.  S, Shak Table 42.2. Optimal treatment of recurrent disease is not clear; in 1979 Herbst reported a 5-year OS after pelvic relapse of 40%.339, Most relapses are local or locoregional, although the incidence of distant relapse in CCAC is higher than in squamous vaginal cancers. Independent clinical, histological and quantitative prognostic factors in transitional‐cell bladder tumours, with special reference to mitotic frequency P. K. Lipponen Corresponding Author  SE, Gion In a Surveillance, Epidemiology, and End Results population-based study with a mix of treatments, the association between ER and survival prognosis was nonproportional over time.26 That is, patients with ER-positive tumors had better survival in early years after diagnosis, and the survival improved for individuals with ER-negative tumors at and after 7 years, because of constant ER-positive mortality hazard rates and decreasing ER-negative hazard rates after peaking at 17 months. To their previous level of intracellular accumulation diagnosed cancer and perhaps in other monotherapy groups and the nature of prognostic! For p53 expression on OS and RFS in patients with IBC ( P < ). Categorical variables between p53-positive and p53-negative groups were compared by log-rank test versus in... 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